Titiyo discovered her own singing abilities when invited by her older sister (Neneh) to sing with her at a studio in London. She fronted her own band in 1987 and played the Stockholm circuit, and signed with a local label, Telegram, in 1989, She also sang background vocals for a range of Swedish artists, including Army of Lovers and Jakob Hellman. In 1989, Titiyo released her self-titled debut album, which topped at #3 in Sweden, and was released in the United States on Arista, and became one of the contributions to a Swedish R & B wave in the US that lasted throughout the nineties. The single "My Body Says Yes" was a hit in North America, and "Talking to the Man in the Moon" reached #6 in the Swedish charts; the subsequent single, "After the Rain," reached #13.
Titiyo took a two-year break and returned in 1993 with the Aretha Franklin cover "Never Let Me Go" (a hit that reached number 25 on Swedish chart), later included on her second full-length - This is Titiyo. Remixes of this and some of her other songs were popular in the London club scene. Her third album, Extended, produced by Kent (Gillström) Isaacs (released by the Swedish label Diesel Music), appeared in 1997, producing the hit single "Josefin Dean" (named after Mariah Carey's best friend).
In 2001, Titiyo revitalised her career with her successful fourth studio album “Come Along” (released in the US in 2002; also on Diesel Music), spawning the single "Come Along", which became an international hit. Produced and written by Peter Svensson (The Cardigans) and Joakim Berg (Kent), the album and its title song made it to the top of in the Swedish charts, while the single was a success in several European countries including France, Germany, Switzerland, and the Netherlands.
After a lengthy hiatus, Warner Music released a greatest hits album named Best of Titiyo in 2004, which included two new songs. One of these songs, "Loving out of Nothing", charted within the top-20 in Sweden in early 2005.
In spring 2008, Titiyo was asked to contribute vocals to Kleerup's single "Longing for Lullabies". Released in April 2008 in Scandinavia, the single has since reached the top 20 in Denmark and top 10 in Sweden.
Titiyo released her fifth album, Hidden, late 2008. The album mainly feature self-penned material but also results of collaborations with the likes of Kleerup, Moto Boy, and Goran Kajfes of Oddjob.